The Sandringham railway line branches from other southeastern suburban rail lines at South Yarra station. From there, the line follows Chapel Street for most of its length, with no less than five of its stations within walking distance of Melbourne's most iconic shopping thoroughfare.

The line also serves the City of Bayside, with stations at several suburbs on Port Phillip Bay such as Brighton, Beaumaris and Sandringham. Bayside is full of activities and sights such as some of the best beaches in Melbourne, sports clubs and regular community events.